Search results for "Original Articles:Experimental Models of Allergic Disease"

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Comparison of adjuvant and adjuvant-free murine experimental asthma models

2009

Introduction The most widely used protocol for the induction of experimental allergic airway inflammation in mice involves sensitization by intraperitoneal (i.p.) injections of the antigen ovalbumin (OVA) used in conjunction with the adjuvant aluminium hydroxide (alum). Although adjuvants are frequently used, there are questions regarding the necessity of alum for murine asthma studies due to the non-physiological nature of this chemical. Objective The objective of this study was to compare experimental asthma phenotypes between adjuvant and adjuvant-free protocols of murine allergic airway inflammation in an attempt to develop a standardized alternative to adjuvant use. Method An adjuvant-…

medicine.medical_treatmentC57BL/6Aluminum HydroxideintraperitonealMicechemistry.chemical_compoundImmunology and AllergySensitizationMice Inbred BALB CbiologyAluminium hydroxiderespiratory systemPhenotypemedicine.anatomical_structuresubcutaneousFemaleBronchial HyperreactivityBALB/cAdjuvantInjections IntraperitonealOvalbuminInjections SubcutaneousImmunologyOriginal Articles:Experimental Models of Allergic Diseaseβ-galactosidaseSensitivity and Specificitycomplex mixturesBALB/cadjuvantAdjuvants ImmunologicAntigenmedicineAnimalsSkin TestsAsthmaAlumbusiness.industryanimal modelAllergensbeta-Galactosidasebiology.organism_classificationmedicine.diseaseAsthmabehaviourrespiratory tract diseasesMice Inbred C57BLDisease Models AnimalOvalbuminalumchemistryImmunologybiology.proteinbusinessClinical & Experimental Allergy

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